Back to Search
Start Over
Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure.
- Source :
- Biological Research for Nursing; Mar2017, Vol. 19 Issue 2, p153-161, 9p
- Publication Year :
- 2017
-
Abstract
- Aims: To describe correlations and agreement between salivary and serum B-type natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 and determine which biomarkers predict worse functional class in patients with heart failure (HF). Methods: Serum and saliva were collected from 75 hospitalized patients with HF (57 ± 12 years, 43% female, New York Heart Association [NYHA] Classes I [4%], II [43%], and III [53%]). Oral inflammation was rated as good, fair, or poor. Spearman’s ρ and Bland–Altman were used to determine correlations and agreement of the salivary and serum forms of each biomarker. Logistic regressions were used to determine which biomarkers predicted worse NYHA functional class, controlling for depression, body mass index, smoking, and oral inflammation. Results: Median biomarker concentrations were as follows: BNP (serum 361 pg/ml, saliva 9 pg/ml), CRP (serum 13 ng/ml, saliva 25.6 ng/ml), IL-6 (serum 19.3 pg/ml, saliva 10.5 pg/ml), and IL-10 (serum 64.1 pg/ml, saliva 4.7 pg/ml). There was a moderate-to-strong correlation for serum–salivary CRP, weak correlation for serum–salivary IL-6, and no correlations for serum–salivary BNP and IL-10. The Bland–Altman test showed good salivary–serum agreement for all biomarkers, but as serum concentrations rose, salivary measures underestimated serum levels. Visible oral inflammation was the only predictor of worse NYHA class. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTICS
MENTAL depression
SALIVA analysis
BIOMARKERS
COLLECTION & preservation of biological specimens
C-reactive protein
CARDIAC patients
HEART failure
IMMUNOASSAY
INFLAMMATION
INTERLEUKINS
INTERVIEWING
LIFE skills
RESEARCH methodology
ORAL hygiene
PEPTIDE hormones
PERIODONTAL disease
PERIODONTIUM examination
QUESTIONNAIRES
RESEARCH funding
SCALE analysis (Psychology)
SMOKING
STATISTICS
COMORBIDITY
LOGISTIC regression analysis
DATA analysis
SECONDARY analysis
BODY mass index
RANDOMIZED controlled trials
CROSS-sectional method
SEVERITY of illness index
DISEASE duration
DISEASE progression
PHYSICAL activity
DATA analysis software
FUNCTIONAL assessment
DESCRIPTIVE statistics
PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 10998004
- Volume :
- 19
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Biological Research for Nursing
- Publication Type :
- Academic Journal
- Accession number :
- 121309926
- Full Text :
- https://doi.org/10.1177/1099800416665197