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High-Yielding Automated Convergent Synthesis of No-Carrier-Added [11C-Carbonyl]-Labeled Amino Acids Using the Strecker Reaction.
- Source :
- Synlett; 2017, Vol. 28 Issue 3, p371-375, 5p
- Publication Year :
- 2017
-
Abstract
- A new variant of the Strecker synthesis using no-carrier-added [<superscript>11</superscript>C]cyanide for the synthesis of radiolabeled amino acids is described. The protocol is fully automated using a radiochemistry synthesis module and applied to the production of a number of new PET radiotracers. [<superscript>11</superscript>C-Carbonyl]sarcosine, [<superscript>11</superscript>C-carbonyl]methionine, [<superscript>11</superscript>Ccarbonyl]- N-phenylglycine, and [<superscript>11</superscript>C-carbonyl]glycine are all synthesized in moderate to good radiochemical yields. The synthesis of [11C-carbonyl] sarcosine has been validated for production of doses for clinical use, and preliminary evaluation of the new radiotracer in PC3 tumor-bearing mice is also reported. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHEMICAL synthesis
AMINO acid synthesis
RADIOACTIVE tracers
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 28
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 121090781
- Full Text :
- https://doi.org/10.1055/s-0036-1588638