Univariate and Multivariate Generalized Multiscale Entropy to Characterise EEG Signals in Alzheimer's Disease.

Alzheimer's disease (AD) is a degenerative brain disorder leading to memory loss and changes in other cognitive abilities. The complexity of electroencephalogram (EEG) signals may help to characterise AD. To this end, we propose an extension of multiscale entropy based on variance (MSE_σ2) to multichannel signals, termed multivariate MSE_σ2 (mvMSE_σ2), to take into account both the spatial and time domains of time series. Then, we investigate the mvMSE_σ2 of EEGs at different frequency bands, including the broadband signals filtered between 1 and 40 Hz, θ, α, and β bands, and compare it with the previously-proposed multiscale entropy based on mean (MSE), multivariate MSEμ (mvMSEμ), and MSE_σ2, to distinguish different kinds of dynamical properties of the spread and the mean in the signals. Results from 11 AD patients and 11 age-matched controls suggest that the presence of broadband activity of EEGs is required for a proper evaluation of complexity. MSE_σ2 and mvMSE_σ2 results, showing a loss of complexity in AD signals, led to smaller p-values in comparison with MSE_μ and mvMSE_μ ones, suggesting that the variance-based MSE and mvMSE can characterise changes in EEGs as a result of AD in a more detailed way. The p-values for the slope values of the mvMSE curves were smaller than for MSE at large scale factors, also showing the possible usefulness of multivariate techniques. [ABSTRACT FROM AUTHOR]