Back to Search
Start Over
Depression and anxiety were low amongst virally suppressed, long-term treated HIV-infected individuals enrolled in a public sector antiretroviral program in Thailand.
- Source :
- AIDS Care; Mar2017, Vol. 29 Issue 3, p299-305, 7p
- Publication Year :
- 2017
-
Abstract
- HIV/AIDS and anxiety/depression are interlinked. HIV-infected patients suffering from depression may be at risk for poor adherence which may contribute to HIV disease progression. Additionally, an HIV diagnosis and/or using certain antiretroviral agents may trigger symptoms of anxiety/depression. The objective of the study was to assess the prevalence and factors associated with anxiety and depression in HIV-infected patients from the Thai National HIV Treatment Program. This cross-sectional study was performed from January 2012 to December 2012 in HIV-infected out-patients, aged ≥18 years, from three HIV referral centers. Symptoms of anxiety and depression were measured using the Thai-validated Hospital Anxiety and Depression Scale (HADS). A score of ≥11 was defined as having anxiety and depression. Associated factors were assessed by multivariate logistic regression. Totally 2023 (56% males) patients were enrolled. All patients received antiretroviral therapy (ART) for a mean duration of 7.7 years. Median CD4 was 495 cells/mm3. Ninety-five percent had HIV-RNA < 50 copies/ml. Thirty-three percent were currently on efavirenz (EFV)-based ART. The prevalence of anxiety and depression were 4.8% and 3.1%, respectively. About 1.3% had both anxiety and depression. In multivariate logistic models, the female sex [OR = 1.6(95%CI 1.1–2.3),p = .01], having adherence <90% [OR = 2.2(95%CI 1.5–3.4),p < .001], fair/poor quality of life (QOL) [OR = 7.2 (95%CI 3.6–14.2),p < .001] and EFV exposure [OR = 1.6(95%CI 1.1–2.3),p = .01], were independently associated with having anxiety or depression. Our findings demonstrated that prevalence of depression and anxiety was low amongst virally suppressed, long-term antiretroviral-treated HIV-infected individuals. Some key characteristics such as the female sex, poor adherence, poor/fair QOL and EFV exposure are associated with anxiety and depression. These factors can be used to distinguish who would need a more in-depth evaluation for these psychiatric disorders. [ABSTRACT FROM PUBLISHER]
- Subjects :
- ANTI-HIV agents
EFAVIRENZ
ANXIETY
CONFIDENCE intervals
MENTAL depression
DRUGS
HIV infections
PSYCHOLOGY of HIV-positive persons
PATIENT compliance
PROBABILITY theory
QUALITY of life
RESEARCH funding
SEX distribution
VIRAL load
MULTIPLE regression analysis
DISEASE prevalence
CROSS-sectional method
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 09540121
- Volume :
- 29
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- AIDS Care
- Publication Type :
- Academic Journal
- Accession number :
- 120932005
- Full Text :
- https://doi.org/10.1080/09540121.2016.1201194