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Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity.
- Source :
- Journal of Basic & Clinical Physiology & Pharmacology; 11/1/2015, Vol. 26 Issue 6, p555-562, 8p
- Publication Year :
- 2015
-
Abstract
- Background: Novel hepatoprotectives are needed to address the increasing cases of liver problems worldwide. Pterocarpus erinaceus Poir (Fabaceae) ethanol stem bark extract (PE) and its constituent flavonoid, homopterocarpin (HP), were investigated for their protective property in acetaminophen-induced oxidative stress and liver damage. Methods: Adult male albino rats were divided into nine groups. Seven groups were pretreated with PE (50-, 100-, and 150 mg/kg), HP (25-, 50-, and 75 mg/kg) or silymarin (25 mg/kg), respectively, once daily for 5 consecutive days and then administered acetaminophen (2 g/kg) on the 5th day. The control and acetaminophen-intoxicated groups received normal saline throughout the experimental period, with the latter group additionally receiving 2 g/kg acetaminophen on the 5th day. Administrations were performed po. Results: In the acetaminophen-intoxicated group, there were significant increases (p < 0.05) in serum activities of alanine aminotransferase (31.72±3.3 vs. 22.1±1.2 U/I), aspartate aminotransferase (185.1±10.1 vs. 103.83±13.3 U/I), bilirubin level and hepatic malondialdehyde (2.32±0.3 vs. 1.42±0.1 units/mg protein), accompanied with significant decreases (p < 0.05) in hepatic reduced glutathione level (0.10±0.01 vs. 0.23±0.03 units/mg protein) and glutathione peroxidase activity (2.51±0.2 vs. 3.25±0.2 μmol H<subscript>2</subscript>O<subscript>2</subscript> consumed/min/mg protein) compared with the control. Conclusions: PE and HP ameliorated most of the observed biochemical alterations with HP appearing to show more potency. The results suggest that the flavonoid, homopterocarpin contributes to the hepatoprotective and antioxidant potentials of P. erinaceus extract. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEPATOTOXICOLOGY
ACETAMINOPHEN
ANIMAL experimentation
ANTIOXIDANTS
BILIRUBIN
BIOCHEMISTRY
FLAVONOIDS
LIVER diseases
LIVER function tests
PHENOMENOLOGY
MOLECULAR structure
RATS
PHYTOCHEMICALS
PLANT extracts
OXIDATIVE stress
AFRICAN traditional medicine
DATA analysis software
DESCRIPTIVE statistics
ONE-way analysis of variance
PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 07926855
- Volume :
- 26
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Basic & Clinical Physiology & Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 120926680
- Full Text :
- https://doi.org/10.1515/jbcpp-2014-0095