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Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial.
Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial.
- Source :
- British Journal of Psychiatry; Jan2017, Vol. 210 Issue 1, p61-66, 6p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Interventions that improve cognitive function in Alzheimer's disease are urgently required.<bold>Aims: </bold>To assess whether a novel cognitive training paradigm based on 'chunking' improves working memory and general cognitive function, and is associated with reorganisation of functional activity in prefrontal and parietal cortices (trial registration: ISRCTN43007027).<bold>Method: </bold>Thirty patients with mild Alzheimer's disease were randomly allocated to receive 18 sessions of 30 min of either adaptive chunking training or an active control intervention over approximately 8 weeks. Pre- and post-intervention functional magnetic resonance imaging (fMRI) scans were also conducted.<bold>Results: </bold>Adaptive chunking training led to significant improvements in verbal working memory and untrained clinical measures of general cognitive function. Further, fMRI revealed a bilateral reduction in task-related lateral prefrontal and parietal cortex activation in the training group compared with controls.<bold>Conclusions: </bold>Chunking-based cognitive training is a simple and potentially scalable intervention to improve cognitive function in early Alzheimer's disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- SHORT-term memory
ALZHEIMER'S disease
COGNITIVE training
PREFRONTAL cortex
FUNCTIONAL magnetic resonance imaging
HEALTH outcome assessment
COMPARATIVE studies
FRONTAL lobe
MAGNETIC resonance imaging
RESEARCH methodology
MEDICAL cooperation
PARIETAL lobe
RESEARCH
RESEARCH funding
TRANSFER of training
EVALUATION research
RANDOMIZED controlled trials
REHABILITATION of Alzheimer's patients
EXECUTIVE function
Subjects
Details
- Language :
- English
- ISSN :
- 00071250
- Volume :
- 210
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- British Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 120703665
- Full Text :
- https://doi.org/10.1192/bjp.bp.116.182048