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Benefits of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes.
- Source :
- Diabetes/Metabolism Research & Reviews; Jan2017, Vol. 33 Issue 1, pn/a-N.PAG, 11p
- Publication Year :
- 2017
-
Abstract
- <bold>Background: </bold>Means to reduce future risk for cardiovascular disease in subjects with type 2 diabetes are urgently needed.<bold>Methods: </bold>Thirty-two patients with type 2 diabetes (age 59 ± 8 years) followed a Paleolithic diet for 12 weeks. Participants were randomized to either standard care exercise recommendations (PD) or 1-h supervised exercise sessions (aerobic exercise and resistance training) three times per week (PD-EX).<bold>Results: </bold>For the within group analyses, fat mass decreased by 5.7 kg (IQR: -6.6, -4.1; p < 0.001) in the PD group and by 6.7 kg (-8.2, -5.3; p < 0.001) in the PD-EX group. Insulin sensitivity (HOMA-IR) improved by 45% in the PD (p < 0.001) and PD-EX (p < 0.001) groups. HbA1c decreased by 0.9% (-1.2, -0.6; p < 0.001) in the PD group and 1.1% (-1.7, -0.7; p < 0.01) in the PD-EX group. Leptin decreased by 62% (p < 0.001) in the PD group and 42% (p < 0.001) in the PD-EX group. Maximum oxygen uptake increased by 0.2 L/min (0.0, 0.3) in the PD-EX group, and remained unchanged in the PD group (p < 0.01 for the difference between intervention groups). Male participants decreased lean mass by 2.6 kg (-3.6, -1.3) in the PD group and by 1.2 kg (-1.3, 1.0) in the PD-EX group (p < 0.05 for the difference between intervention groups).<bold>Conclusions: </bold>A Paleolithic diet improves fat mass and metabolic balance including insulin sensitivity, glycemic control, and leptin in subjects with type 2 diabetes. Supervised exercise training may not enhance the effects on these outcomes, but preserves lean mass in men and increases cardiovascular fitness. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Subjects :
- BLOOD sugar analysis
TYPE 2 diabetes treatment
ADIPOSE tissues
COMBINED modality therapy
COMPARATIVE studies
EXERCISE therapy
GLYCEMIC index
GLYCOSYLATED hemoglobin
INSULIN resistance
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
OBESITY
PROGNOSIS
RESEARCH
STATISTICAL sampling
EVALUATION research
RANDOMIZED controlled trials
OXYGEN consumption
PALEO diet
Subjects
Details
- Language :
- English
- ISSN :
- 15207552
- Volume :
- 33
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Diabetes/Metabolism Research & Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 120690457
- Full Text :
- https://doi.org/10.1002/dmrr.2828