Interleukin 10 level is correlated with SOFA score but not procalcitonine during sepsis.

Introduction: New findings suggest that there are two distinguished stage of sepsis: early one is dominated by an inflammatory profile of cytokine and the late one by an anti-inflammatory profile of cytokine with mainly interleukin 10 (IL-10). The level of IL-10 has been suggested to be related with clinical worsening during sepsis. Our aim was to study the correlation between the level of IL-10 and SOFA score during sepsis. Methods: Septic patients were enrolled in a prospective descriptive study. Blood samples were collected at three times: hour 0 (H0), H24 and H48. H0 was the Diagnosis of sepsis time. Serum levels of IL-10, TNF and IL-6 were measured with the technique of a solid-phase, two-site chemiluminescence enzyme immunometric assay (Immulite 1000, Siemens, USA). Procalcitonin (PCT) was measured at H0, H24 and H48. SPSS 11.0 was used. Friedman test was used to compare nonparametric variables. It is statistically significant if p<0.05. Correlations between variables were determined by using the Pearson correlation analysis for normally distributed variables. Quantitative variables are expressed as median (Interquartile range). Results: Twenty six patients were included. There was an elevation of IL-6 and IL-10 during the first 24h. The mean value of IL-6 at H24 was higher than H0: respectively 114.99 pg/ml [10.32-50.35] and 117.13 [21.7-118.2] but not statistically significant (p=0.6). The mean value of IL-10 at H24 was higher than H0 respectively: 30.75 [5-21.85] and 59.28 [13.8-39] but not statistically significant (p=0.11). At 48 hours, IL-6 and IL-10 were decreased respectively 22.9 [15.8-28.4] and 8.76 [4.35-12.55]. P was not significant. There was no significant change of TNF level at different times. PCT levels at H0, H24 and H48 were respectively: 2.1 [0.2-4.1], 0.7 [0.24-0.7] and 6.16 [0.05-14.9]. P was not significant (p=0.3). There was a correlation between the level of IL-10 and SOFA score at H0 (R=0.8/p=0.039) but it wasn't a correlation between TNF, IL-6 and proclacitonine with SOFA score. Conclusions: Level of IL-10, mainly at H0, is correlated with prognosis during sepsis. Therefore, these cytokines might be a new tools for management of this pathology. However, further studies are needed to confirm our results. [ABSTRACT FROM AUTHOR]