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Review Paper: Role of Nitric Oxide on Dopamine Release and Morphine-Dependency.
- Source :
- Basic & Clinical Neuroscience; 2016, Vol. 7 Issue 4, p283-290, 8p
- Publication Year :
- 2016
-
Abstract
- The catastrophic effects of opioids use on public health and the economy are documented clearly in numerous studies. Repeated morphine administration can lead to either a decrease (tolerance) or an increase (sensitization) in its behavioral and rewarding effects. Morphine-induced sensitization is a major problem and plays an important role in abuse of the opioid drugs. Studies reported that morphine may exert its effects by the release of nitric oxide (NO). NO is a potent neuromodulator, which is produced by nitric oxide synthase (NOS). However, the exact role of NO in the opioid-induced sensitization is unknown. In this study, we reviewed the role of NO on opioid-induced sensitization in 2 important, rewarding regions of the brain: nucleus accumbens and ventral tegmentum. In addition, we focused on the contribution of NO on opioid-induced sensitization in the limbic system. [ABSTRACT FROM AUTHOR]
- Subjects :
- NITRIC oxide
DOPAMINE
MORPHINE abuse
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 2008126X
- Volume :
- 7
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Basic & Clinical Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 120369030
- Full Text :
- https://doi.org/10.15412/J.BCN.03070401