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Prenatal unhealthy diet, insulin-like growth factor 2 gene (IGF2) methylation, and attention deficit hyperactivity disorder symptoms in youth with early-onset conduct problems.
- Source :
- Journal of Child Psychology; Jan2017, Vol. 58 Issue 1, p19-27, 9p, 1 Diagram, 1 Chart
- Publication Year :
- 2017
-
Abstract
- Background: Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to 'unhealthy diet'. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth. Methods: Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7-13) differed for EOP versus low CP youth. Results: Prenatal 'unhealthy diet' was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal 'unhealthy diet' was associated with higher ADHD symptoms indirectly via higher IGF2 methylation. Conclusions: Preventing 'unhealthy diet' in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation. [ABSTRACT FROM AUTHOR]
- Subjects :
- AGE factors in disease
ATTENTION-deficit hyperactivity disorder
BEHAVIOR disorders in children
CHI-squared test
COMPARATIVE studies
DIET
DNA
FACTOR analysis
FAT content of food
GENES
GESTATIONAL age
LONGITUDINAL method
METHYLATION
PRENATAL care
PROBABILITY theory
QUESTIONNAIRES
REGRESSION analysis
RESEARCH funding
MATHEMATICAL variables
COMORBIDITY
SAMPLE size (Statistics)
REPEATED measures design
DATA analysis software
DESCRIPTIVE statistics
DIETARY sucrose
PREGNANCY
SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 00219630
- Volume :
- 58
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Child Psychology
- Publication Type :
- Academic Journal
- Accession number :
- 120346541
- Full Text :
- https://doi.org/10.1111/jcpp.12589