Effect of a Long-Term Physical Activity Intervention on Resting Pulse Rate in Older Persons: Results from the Lifestyle Interventions and Independence for Elders Study.

Objectives To assess the utility of a long-term physical activity ( PA) intervention for reducing resting pulse rate ( RPR) in older persons. Design Community. Setting Lifestyle Interventions and Independence for Elders Study. Participants Individuals aged 70 to 89 (N = 1,635, 67.2% women) were randomized to a moderate-intensity PA intervention (n = 818) or a health education-based successful aging ( SA) intervention (n = 817). Measurements RPR was recorded at baseline and 6, 18, and 30 months. Longitudinal changes in RPR of intervention groups were compared using a mixed-effects analysis of covariance model for repeated-measure outcomes, generating least squares means with standard errors ( SEs) or 95% confidence intervals ( CIs). Results Mean duration of the study was 2.6 years (median 2.7 years, interquartile range 2.3-3.1 years). The average effect of the PA intervention on RPR over the course of the study period was statistically significant but clinically small (average intervention difference = 0.84 beats/min; 95% CI = 0.17-1.51; P_average = .01), with the most pronounced effect observed at 18 months ( PA, 66.5 beats/min ( SE 0.32 beats/min); SA, 67.8 beats/min ( SE 0.32 beats/min); difference = 1.37 beats/min, 95% CI = 0.48-2.26 beats/min). The relationship became somewhat weaker and was not statistically significant at 30 months. There were no significant differences between several prespecified subgroups. Conclusion A long-term moderate-intensity PA program was associated with a small and clinically insignificant slowing of RPR in older persons. Whether PA can deliver a beneficial reduction in RPR requires further examination in older adults. [ABSTRACT FROM AUTHOR]