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Improved local and regional control with radiotherapy for Merkel cell carcinoma of the head and neck.
- Source :
- Head & Neck; Jan2017, Vol. 39 Issue 1, p48-55, 8p
- Publication Year :
- 2017
-
Abstract
- Background We hypothesized that radiotherapy (RT) would improve both local and regional control with Merkel cell carcinoma of the head and neck. Methods A single-institution institutional review board-approved study was performed including 113 patients with nonmetastatic Merkel cell carcinoma of the head and neck. Postoperative RT was delivered to the primary tumor bed (71.7% cases) ± draining lymphatics (33.3% RT cases). Results Postoperative local RT was associated with improved local control (3-year actuarial local control 89.4% vs 68.1%; p = .005; Cox hazard ratio [HR] 0.18; 95% confidence interval [CI] = 0.06-0.55; p = .002). Similarly, regional RT was associated with improved regional control (3-year actuarial regional control 95.0% vs 66.7%; p = .008; Cox HR = 0.09; 95% CI = 0.01-0.69; p = .02). Regional RT played an important role for both clinical node-negative patients (3-year regional control 100% vs 44.7%; p = .03) and clinical/pathological node-positive patients (3-year regional control 90.9% vs 55.6%; p = .047). Conclusion Local RT was beneficial for all patients with Merkel cell carcinoma of the head and neck, whereas regional RT was beneficial for clinical node-negative and clinical/pathological node-positive patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 48-55, 2017 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10433074
- Volume :
- 39
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Head & Neck
- Publication Type :
- Academic Journal
- Accession number :
- 120262564
- Full Text :
- https://doi.org/10.1002/hed.24527