Applying discrete SEIR model to characterizing MERS spread in Korea.

Since the first outbreak of Middle East Respiratory Syndrome (MERS), Korea has a quite rapid MERS spread compared to other countries. Possible causes for such a sudden increase include the undiagnosed initial patient and lapses in infection control practices. To characterize MERS infection and transmission, this paper applies the period-based discrete SEIR model. Infected people of SEIR model shows a good fit to observed patients and MERS will become extinct around 113 days since the first outbreak. Through an effective quarantine plan, if we can reduce exposable people by 20%, it is estimated that the maximum number of infectious people may decrease by about 69% and MERS fade-out period will be shortened by about 30%. Simulations on assumed model support that Korean government's two policies to control MERS infection rate are effective in lessening its spread. Simulation on reproduction ratio scenarios in SEIR model indicates that success in early infection control practices is critical for shortening the period of disease fade-out. Even there are some restrictions and assumptions on SEIR model simulation, our simulation results are to be helpful in developing strategies to prevent the infectious diseases like MERS. [ABSTRACT FROM AUTHOR]