Back to Search
Start Over
Transcranial Doppler-Based Surrogates for Cerebral Blood Flow: A Statistical Study.
- Source :
- PLoS ONE; 11/23/2016, Vol. 11 Issue 11, p1-15, 15p
- Publication Year :
- 2016
-
Abstract
- It is commonly assumed that perfusion in a given cerebral territory can be inferred from Blood Flow Velocity (BFV) measurements in the corresponding stem artery. In order to test this hypothesis, we construct a cerebral blood flow (CBF) estimator based on transcranial Doppler (TCD) blood flow velocity and ten other easily available patient characteristics and clinical parameters. A total of 261 measurements were collected from 88 older patients. The estimator is based on local regression (Random Forest). Its performance is analyzed against baseline CBF from 3-D pseudocontinuous arterial spin labeling (pCASL) magnetic resonance imaging (MRI). Patient specific CBF predictions are of poor quality (r = 0.41 and p-value = 4.5 × 10<superscript>−12</superscript>); the hypothesis is thus not clearly supported by evidence. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 119742695
- Full Text :
- https://doi.org/10.1371/journal.pone.0165536