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The −2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene (MCP-1) is associated with an increased risk of rheumatoid arthritis in Argentine patients.
- Source :
- Clinical Rheumatology; Dec2016, Vol. 35 Issue 12, p3057-3061, 5p
- Publication Year :
- 2016
-
Abstract
- The aim of this study was to analyze the influence of nucleotide transition (G/A) in position −2518 of the MCP-1 gene related to the susceptibility of developing RA. Two hundred twenty-three consecutive RA patients according to 2010 ACR/EULAR criteria were included; 120 healthy subjects were used as controls. MCP-1 −2518 A/G polymorphism (AG + GG) was present in 162 (72.6 %) RA patients and in 63 (52.5 %) healthy subjects [OR 2.44 (IC95% 1.53-3.88, p = 0.0002)]; associations for heterozygotes and homozygotes were OR 1.92 (IC95% 1.19-3.15, p = 0.001) and OR 5.19 (IC95% 2.34-11.51, p = 0.001), respectively. In Argentine patients, MCP-1 gene polymorphism confers susceptibility for developing RA. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07703198
- Volume :
- 35
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Clinical Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 119597216
- Full Text :
- https://doi.org/10.1007/s10067-016-3380-0