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Evaluating the Primary Prevention of Ischemic Stroke of Oral Antithrombotic Therapy in Head and Neck Cancer Patients with Radiation Therapy.
- Source :
- BioMed Research International; 11/21/2016, Vol. 2016, p1-9, 9p
- Publication Year :
- 2016
-
Abstract
- Although previous studies demonstrated the risk of ischemic stroke (IS) in patients with head and neck cancer (HNC), the impact of oral antithrombotic therapy (OAT) on this risk has not yet been assessed. We aimed to evaluate the effectiveness and safety of OAT in patients with HNC treated with RT. This retrospective cohort study was performed using the National Health Insurance Research Database of Taiwan. A total of 37,638 patients diagnosed with HNC included in the study were classified as users and nonusers of OAT. Primary outcome was IS or transient ischemic attack (TIA), and secondary outcomes were death and major bleeding. The Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). There was no significant difference in the risk of IS or TIA between patients on continuous OAT and nonusers (adjusted HR, 0.812; 95% CI, 0.199–3.309). The risk of major bleeding was not significantly different between the groups. From a national population database, we did not find an association between OAT and decreasing risk of ischemic stroke/TIA or increasing hazard of major bleeding. [ABSTRACT FROM AUTHOR]
- Subjects :
- STROKE risk factors
STROKE prevention
FIBRINOLYTIC agents
CHI-squared test
CONFIDENCE intervals
HEAD tumors
HEMORRHAGE
MORTALITY
NECK tumors
PROBABILITY theory
RESEARCH funding
STROKE
T-test (Statistics)
TREATMENT effectiveness
DISEASE incidence
PROPORTIONAL hazards models
RETROSPECTIVE studies
DATA analysis software
DESCRIPTIVE statistics
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2016
- Database :
- Complementary Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 119593386
- Full Text :
- https://doi.org/10.1155/2016/6205158