A molecular imprinted polymer on the surface of superparamagnetic Fe3O4-graphene oxide (MIP@Fe3O4@GO) for simultaneous recognition and enrichment of evodiamine and rutaecarpine in Evodiae fructus.

ABSTRACT A composite material (MIP@Fe₃O₄@GO) based on molecular imprinted polymer (MIP), superparamagnetic Fe₃O₄ particles and graphene oxide (GO) was prepared by the chemical coprecipitation method, and used to simultaneously separate and enrich two alkaloids (evodiamine and rutaecarpine) in the extract of Evodiae fructus. The as-prepared MIP@Fe₃O₄@GO was characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The adsorption kinetics, isotherms, competitive adsorption, and reusability of MIP@Fe₃O₄@GO were also investigated. The results revealed that MIP@Fe₃O₄@GO was sensitive to the magnetic field and could be easily separated using an external magnet; MIP@Fe₃O₄@GO showed good recognition selectivity, as well as simultaneous enrichment and separation abilities for evodiamine and rutaecarpine in the extract of E. fructus with satisfactory recoveries. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44465. [ABSTRACT FROM AUTHOR]