Re-evaluation of progenitor thresholds and expectations for haematopoietic recovery based on an analysis of 810 autologous transplants: Implications for quality assurance.

Haematological engraftment was assessed in 804 autologous transplants. Neutrophil recovery occurred in over 99% within 14 d but platelet recovery was delayed beyond this time in 14·8%. Time to recovery was dependent on the progenitor cell dose infused. The minimum CD34⁺ cell threshold adopted in this study (2 × 10⁶/kg) was safe although recovery was faster with a dose >5 × 10⁶/kg. CD34⁺ cell doses of between 1 and 2 × 10⁶/kg were also acceptable if either the granulocyte-macrophage colony-forming cell dose exceeded 2 × 10⁵/kg or this dose was due to splitting a higher yield harvest. Prompt neutrophil recovery affords important quality assurance for laboratory processing. [ABSTRACT FROM AUTHOR]