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Trajectories of Lower Extremity Physical Performance: Effects on Fractures and Mortality in Older Women.
- Source :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Dec2016, Vol. 71 Issue 12, p1609-1615, 7p, 3 Charts
- Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>Prior studies have only considered one measurement of physical performance in its relationship to fractures and mortality. A single measurement is susceptible to large within-person changes over time, and thus, may not capture the true association between physical performance and the outcomes of interest.<bold>Methods: </bold>Using data from the Study of Osteoporotic Fractures, we followed 7,015 women enrolled prior to age 80 years who had outcome information beyond this age. Trajectories of walking speed (m/s) and chair stand speed (stands/s) were estimated up to the last visit prior to age 80 years using mixed-effects linear regression. Physical performance at age 80 (PF_age80) was assessed at the last visit prior to age 80 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression and multivariate models adjusted for all other covariates.<bold>Results: </bold>Greatest walking speed decline and chair stand speed decline were both associated with higher risk of hip fracture (HR: 1.28; 95% CI: 1.03, 1.58 and HR: 1.26; 95% CI: 1.03, 1.54, respectively), but not nonspine fractures. Greatest walking speed decline and chair stand speed decline were both associated with a significant 29% (95% CI: 17-42%) and 27% (95% CI: 15-39%) increased risk of mortality, respectively.<bold>Conclusions: </bold>Greatest declines in walking speed and chair stand speed were both associated with an increased risk of hip fracture and mortality independent of PF_age80 and other important confounders. Both physical performance change and the single physical performance measurement should be considered in the etiology of hip fracture and mortality. [ABSTRACT FROM AUTHOR]
- Subjects :
- BONE fractures
CONFIDENCE intervals
META-analysis
PROPORTIONAL hazards models
REGRESSION analysis
GERIATRIC assessment
COMPARATIVE studies
HIP joint injuries
LEG
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
MORTALITY
RESEARCH
RESEARCH funding
SYMPTOMS
EVALUATION research
CONFOUNDING variables
Subjects
Details
- Language :
- English
- ISSN :
- 10795006
- Volume :
- 71
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 119453051
- Full Text :
- https://doi.org/10.1093/gerona/glw071