Back to Search Start Over

The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure.

The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure.

Authors :
Yoichiro Okubo
Osamu Motohashi
Norisuke Nakayama
Ken Nishimura
Rika Kasajima
Yohei Miyagi
Manabu Shiozawa
Emi Yoshioka
Masaki Suzuki
Kota Washimi
Kae Kawachi
Madoka Nito
Yoichi Kameda
Tomoyuki Yokose
Source :
Diagnostic Pathology; 11/8/2016, Vol. 11, p1-7, 7p
Publication Year :
2016

Abstract

Background: As the World Health Organization grading system for gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) may not always correlate with tumor progression, it is imperative that other independent predictors of tumor progression be established. To identify such predictors, we conducted a retrospective histopathological study of hindgut NETs, obtained from endoscopic procedures, and used statistical analyses to evaluate predictive factors. Methods: We first obtained clinicopathological data of cases of hindgut NETs. Tissue sections from tumor samples were prepared and subjected to pathological examination. In particular, we calculated the microvessel density (MVD) and lymphatic microvessel density (LMVD) values, and performed appropriate statistical analyses. Results: A total of 42 cases of hindgut NETs were selected for the study, 41 from the rectum and 1 from the sigmoid colon. Based on the Ki-67 labeling index, 34 cases were classified as NET G1 tumors and 8 as NET G2 tumors. MVD values ranged from 1.4/mm<superscript>2</superscript> to 73.9/mm<superscript>2</superscript> and LMVD values from 0/mm<superscript>2</superscript> to 22.9/mm<superscript>2</superscript>. MVD and LMVD were identified as risk factors for venous and lymphatic invasion of hindgut NETs. Moreover, MVD positively correlated with the maximum diameter of the tumor. Conclusions: Tumor progression of NETs may cause angiogenesis and lymphangiogenesis, via an unknown mechanism, as well as lymphovascular invasion. Angiogenesis likely plays an important role in occurrence and progression in the initial phase of hindgut NETs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17461596
Volume :
11
Database :
Complementary Index
Journal :
Diagnostic Pathology
Publication Type :
Academic Journal
Accession number :
119439520
Full Text :
https://doi.org/10.1186/s13000-016-0580-5