Synthesis, crystal structure, and Helicobacter pylori urease inhibition of a dicyanoamide bridged Cu(I/II) complex.

A dicyanoamide-bridged polymeric copper(I/II) complex, [Cu^II(sal)(bipy) Cu^I(dca)₂]_n, was prepared by reaction of 5-methylchlorosalicylaldehyde (Hsal), 2,2'-bipyridine (bipy), sodium dicyanoamide (Nadca), and copper perchlorate in methanol. The complex was characterized by elemental analyses, infrared and electronic spectroscopy, and single-crystal X-ray determination. Cu^II has a square pyramidal coordination, and Cu^I has triangular coordination. The complex showed high urease inhibitory activity with IC₅₀ value of 0.16 ± 0.23 μM. [ABSTRACT FROM AUTHOR]