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Enantioselective Direct Alkynylation of Ketones Catalyzed by Chiral CCN Pincer RhIII Complexes.
- Source :
- Chemistry - A European Journal; 11/14/2016, Vol. 22 Issue 47, p16801-16804, 4p
- Publication Year :
- 2016
-
Abstract
- A direct asymmetric alkynylation of ketones with new chiral CCN Rh catalysts containing N-heterocyclic carbene and oxazoline hybrid ligands is described. The catalytic reaction of fluoroalkyl-substituted ketones, ArCOCF<subscript>2</subscript>X (X=F, Cl, H), with aromatic and aliphatic alkynes yielded the corresponding chiral propargyl alcohols with high enantioselectivity. Control and kinetic experiments suggested a bis(alkynyl) Rh intermediate as the active species for the CāC bond-forming step. [ABSTRACT FROM AUTHOR]
- Subjects :
- KETONES
ALKYNES
ENANTIOSELECTIVE catalysis
CARBENES
OXAZOLINE
LIGANDS (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 22
- Issue :
- 47
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 119336014
- Full Text :
- https://doi.org/10.1002/chem.201603754