Back to Search
Start Over
Outcomes of on-site antiretroviral therapy provision in a South African correctional facility.
- Source :
- International Journal of STD & AIDS; Nov2016, Vol. 27 Issue 13, p1153-1161, 9p, 1 Diagram, 1 Chart, 2 Graphs
- Publication Year :
- 2016
-
Abstract
- We evaluated a novel on-site antiretroviral therapy (ART) programme in a South African correctional facility using routinely collected programme data, from a retrospective cohort of adult inmates starting ART between 03/2007 and 03/2009 followed-up to 09/2009. We report (1) mortality (using survival analysis); (2) retention in the programme (to 09/2009); and (3) virological suppression at six and 12 months (<400 copies/ml) following ART initiation. In total, 404 started ART (median age 33 years; 91.3% men; median baseline CD4 cell count 152 cells/µl [interquartile range 85-225]). Among 299 starting ART for the first time (ART-naïve), 23 deaths occurred during 252 person-years (median follow-up nine months). Mortality rates were 17.2 at 0-6 months (95% confidence interval 10.9-26.9) and 2.8 at >6 months (95% confidence interval 1.1-7.5)/100 person-years; p < 0.001. At 09/2009, 35.6% (144/404) remained in the correctional facility, with 94.4% (136/144) retained in the programme; 38.4% (155/404) were released; and 20.0% (81/404) transferred to another facility. ART-naïve patients in care six and 12 months after ART initiation, 94.7% (124/131) and 92.5% (74/80) were virologically suppressed, respectively. High early mortality warrants the early identification and management of HIV-positive inmates. The high mobility of inmates necessitates systems for facilitating continuity of care. Good virological responses and retention supports decentralising HIV care to correctional facilities. [ABSTRACT FROM AUTHOR]
- Subjects :
- MORTALITY of AIDS patients
AIDS treatment
ANTIRETROVIRAL agents
HEALTH programs
FOLLOW-up studies (Medicine)
DIAGNOSIS of HIV infections
ANTI-HIV agents
CONTINUUM of care
CORRECTIONAL institutions
HIV infections
PRISONERS
MEDICAL screening
RESEARCH funding
SURVIVAL analysis (Biometry)
VIRAL load
HIGHLY active antiretroviral therapy
TREATMENT effectiveness
RETROSPECTIVE studies
CD4 lymphocyte count
Subjects
Details
- Language :
- English
- ISSN :
- 09564624
- Volume :
- 27
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- International Journal of STD & AIDS
- Publication Type :
- Academic Journal
- Accession number :
- 119144982
- Full Text :
- https://doi.org/10.1177/0956462415584467