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Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial.
- Source :
- Diabetes Care; Nov2016, Vol. 39 Issue 11, p1909-1914, 6p, 2 Charts, 2 Graphs
- Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>Fibroblast growth factor 21 (FGF21) is involved in the regulation of energy balance and adipose metabolism. Our previous genome-wide association study identified genetic variants in the FGF21 region associated with macronutrient intake preference. We investigated whether the FGF21 genotype modified effects of weight-loss diets varying in macronutrient intake on changes in adiposity in a 2-year randomized diet intervention trial.<bold>Research Design and Methods: </bold>We genotyped FGF21 rs838147 in 715 overweight or obese individuals who were assigned to one of four diets varying in macronutrient contents. A DEXA scan was performed to evaluate body composition.<bold>Results: </bold>We observed a significant interaction between the FGF21 genotype and carbohydrate/fat intake on 2-year changes in waist circumference (WC), percentage of total fat mass, and percentage of trunk fat (P = 0.049, P = 0.001, and P = 0.003 for interaction, respectively). In response to the low-carbohydrate/high-fat diet, carrying the carbohydrate intake-decreasing C allele of rs838147 was marginally associated with less reduction in WC (P = 0.08) and significantly associated with less reduction of total fat mass (P = 0.01) and trunk fat (P = 0.02). Opposite genetic associations with these outcomes were observed among the high-carbohydrate/low-fat diet group; carrying the C allele was associated with a greater reduction of WC, total body fat mass, and trunk fat.<bold>Conclusions: </bold>Our data suggest that FGF21 genotypes may interact with dietary carbohydrate/fat intake on changes in central adiposity and body fat composition. A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENOTYPES
WEIGHT loss
OBESITY
BODY composition
DIET
ADIPOSE tissues
ALLELES
HUMAN body composition
DIET therapy
CARBOHYDRATE content of food
FAT content of food
GENETIC polymorphisms
GROWTH factors
INGESTION
LOW-fat diet
REDUCING diets
RESEARCH funding
STATISTICAL sampling
RANDOMIZED controlled trials
TREATMENT effectiveness
WAIST circumference
SEQUENCE analysis
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 39
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 119093436
- Full Text :
- https://doi.org/10.2337/dc16-1111