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A Lack of Clinical Effect of High-frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double-blind Trial.
- Source :
- European Eating Disorders Review; Nov2016, Vol. 24 Issue 6, p474-481, 8p, 1 Diagram, 2 Charts, 1 Graph
- Publication Year :
- 2016
-
Abstract
- Studies suggest that stimulation of the left dorsolateral prefrontal cortex (DLPFC) reduces food craving in bulimic patients, but evidence supporting repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool is lacking. We investigated the safety and therapeutic efficacy of an adjunct high-frequency rTMS programme targeting the left DLPFC. Forty-seven women with bulimia nervosa were randomised to a real or sham stimulation group. The real group underwent 10 rTMS sessions, each consisting of 20 trains of 5 seconds with 55-second intervals between trains, at a frequency of 10 Hz. The main outcome was the number of binge episodes in the 15 days following the end of stimulation. Overall, no significant improvement in bingeing and purging symptoms was noted after the programme. rTMS was well tolerated. This suggests that 10 sessions of high-frequency rTMS to the left DLPFC provide no greater benefit than placebo. Future studies should consider methodological issues as well as alternative targets. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association. [ABSTRACT FROM AUTHOR]
- Subjects :
- BULIMIA treatment
QUESTIONNAIRES
RESEARCH funding
STATISTICAL sampling
SEROTONIN uptake inhibitors
STATISTICS
TRANSCRANIAL magnetic stimulation
DATA analysis
RANDOMIZED controlled trials
TREATMENT effectiveness
REPEATED measures design
BLIND experiment
DATA analysis software
MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 10724133
- Volume :
- 24
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- European Eating Disorders Review
- Publication Type :
- Academic Journal
- Accession number :
- 119087907
- Full Text :
- https://doi.org/10.1002/erv.2475