Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells.

The article discusses the association of Wnt signaling with cell survival in the interaction between acute myeloid leukemia cells and stromal cells. It demonstrates the protection of TRL-01 cells from cell death, which is mediated by Wnts secreted from HTS cells. It also investigates the regulation of the antiapoptotic downstream pathway molecules in TRL-01 cells, and the effects of other inhibitors targeted for Wnt signaling.