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Varenicline for smoking cessation and reduction in people with severemental illnesses: systematic review andmetaanalysis.
- Source :
- Addiction; Sep2016, Vol. 111 Issue 9, p1554-1567, 14p, 1 Diagram, 5 Charts
- Publication Year :
- 2016
-
Abstract
- Aims To determine the effectiveness and safety of varenicline in treating tobacco dependence in patients with severe mental illness. Design A systematic reviewand meta-analysis of randomised controlled trials that compared varenicline with a placebo or an alternative intervention for smoking cessation or reduction. Setting Both in- and out-patient settings in any country. Participants Adult patients aged 18 years and over with any type of severe mental illness. The systematic review included eight studies comprising 398 participants. Measures Primary outcome measures were (1) smoking cessation, (2) smoking reduction measured by changes in the number of cigarettes smoked per day and (3) number of psychiatric adverse events, which were collected at the end of treatment. Findings The random-effect pooled estimates from the five studies that reported smoking-related outcomes found that varenicline is statistically superior to placebo in smoking cessation [risk ratios 4.33; 95% confidence interval (CI)=1.96-9.56], and smoking reduction was higher in varenicline groups (mean reduced daily cigarettes was 6.39; 95% CI=2.22-10.56). There is no significant difference regarding neuropsychiatric and other adverse events. Conclusions Varenicline appears to be significantly more effective than placebo in assisting with smoking cessation and reduction in people with severe mental illness. There appears to be no clear evidence that varenicline was associated with an increased risk of neuropsychiatric or other adverse events compared with placebo. [ABSTRACT FROM AUTHOR]
- Subjects :
- VARENICLINE
SMOKING cessation
PEOPLE with mental illness
SMOKING prevention
TREATMENT effectiveness
HEALTH
THERAPEUTICS
CINAHL database
CONFIDENCE intervals
INFORMATION storage & retrieval systems
MEDICAL databases
MEDICAL information storage & retrieval systems
PSYCHOLOGY information storage & retrieval systems
MEDLINE
META-analysis
PLACEBOS
PROBABILITY theory
PSYCHOTHERAPY patients
RESEARCH funding
SMOKING
SYSTEMATIC reviews
RANDOMIZED controlled trials
NICOTINIC agonists
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
Subjects
Details
- Language :
- English
- ISSN :
- 09652140
- Volume :
- 111
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Addiction
- Publication Type :
- Academic Journal
- Accession number :
- 118089321
- Full Text :
- https://doi.org/10.1111/add.13415