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Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis.
- Source :
- Journal of Clinical Research in Pediatric Endocrinology; Sep2016, Vol. 8 Issue 3, p276-281, 6p
- Publication Year :
- 2016
-
Abstract
- Objective: It is suggested that vitamin D is one of the factors that can regulate the function of Treg cells. In this study, the relationships between Treg cells and vitamin D levels was investigated in pediatric chronic autoimmune thyroiditis (CAT) patients. Methods: Thirty-two children with CAT and 24 healthy subjects were studied. FOXP3 expressing CD4+CD25+high Foxp3+T cells were identified as Treg cells. At diagnosis, 25-hydroxycholecalciferol (25OHD3) levels were determined in all patients. FOXP3 expression was measured before and after vitamin D replacement therapy in patients having low levels of 25OHD3. Results: In the CAT patients, Treg cell levels did not differ from the control group, while the frequency of vitamin D deficiency was higher and FOXP3 molecule expression was lower. FOXP3 molecule expression significantly increased in CAT patients having vitamin D deficiency who were given vitamin D replacement. Conclusion: FOXP3 expression is decreased in pediatric CAT patients. This reduction seems to be associated with vitamin D levels. Vitamin D can play a role in enhancing natural Treg cell functions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13085727
- Volume :
- 8
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Research in Pediatric Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 118037435
- Full Text :
- https://doi.org/10.4274/jcrpe.2766