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Alcohol use predicts elevation in inflammatory marker soluble CD14 in men living with HIV.
- Source :
- AIDS Care; Nov2016, Vol. 28 Issue 11, p1434-1440, 7p, 3 Charts, 2 Graphs
- Publication Year :
- 2016
-
Abstract
- Independently, HIV infection and heavy alcohol use increase microbial translocation (MT) of gut products into systemic circulation. MT and consequent immune response have been linked to chronic inflammation and a host of negative health outcomes in individuals living with HIV. However, previous research has not systematically investigated the immune correlates of heavy drinking specifically within the HIV-positive population. This pilot study investigated MT and immune activation as a function of alcohol use in 21 HIV-positive men who met NIAAA criteria for heavy drinking. Participants averaged 46.7 ± 8.5 (mean ± standard deviation) years of age, 12.2 ± 9.2 years since HIV diagnosis, 337 ± 158 CD4 nadir, and 643 ± 245 current CD4 count. All participants were virologically suppressed on antiretroviral therapy. Data on alcohol use and immune function were collected at baseline and three-month follow-up. Plasma concentrations of markers of MT and immune activation (lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody immunoglobulin M (EndoCAb)) were measured using enzyme-linked immunosorbent assays. Generalized estimating equation models tested alcohol use variables as predictors of LPS, sCD14, and EndoCAb levels. Greater quantity and frequency of drinking significantly predicted higher sCD14 levels (p’s < .01). Conversely, longer duration of abstinence from alcohol significantly predicted lower sCD14 levels (p < .001). These results remained significant after controlling for age, HIV duration, smoking status, current CD4 count, CD4 nadir, and antiretroviral drug type. In addition, participants with ≥50% relative reduction in drinks per week showed a significant decrease (p < .05) in sCD14 from baseline to three-month follow-up. This pilot study provides preliminary evidence that heavy drinking may increase a key inflammatory marker in HIV-infected individuals with suppressed infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTI-HIV agents
ANTIGENS
BIOMARKERS
CHI-squared test
ALCOHOL drinking
ENZYME-linked immunosorbent assay
HIV infections
HIV-positive persons
IMMUNOGLOBULINS
INFLAMMATION
MEN'S health
METROPOLITAN areas
PROBABILITY theory
QUESTIONNAIRES
RESEARCH funding
STATISTICS
T-test (Statistics)
PILOT projects
DATA analysis
BINGE drinking
RANDOMIZED controlled trials
DATA analysis software
LIPOPOLYSACCHARIDES
DESCRIPTIVE statistics
CD4 lymphocyte count
MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 09540121
- Volume :
- 28
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- AIDS Care
- Publication Type :
- Academic Journal
- Accession number :
- 118003268
- Full Text :
- https://doi.org/10.1080/09540121.2016.1189497