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N-methyl-d-aspartate (NMDA) receptor antibodies encephalitis mimicking an autistic regression.
- Source :
- Developmental Medicine & Child Neurology; Oct2016, Vol. 58 Issue 10, p1092-1094, 3p
- Publication Year :
- 2016
-
Abstract
- Expressive dysphasia and mutism are common clinical features in children and adults with N-methyl-d-aspartate receptor antibodies (NMDAR-Ab) encephalitis, and are likely to result from NMDAR hypofunction. A prodromal loss of social and communication skills can typify that of an autistic regression, particularly when presenting under the age of 3 years. Here we describe two toddlers who presented with developmental regression, particularly of their social communication skills, mimicking an autistic regression, who were found to have NMDAR-Ab in the serum and cerebrospinal fluid. Although both patients had some other neurological features, they were subtle, which resulted in delayed diagnosis of NMDAR-Ab encephalitis. Importantly, immunotherapy was beneficial in both patients, with significant improvement of their language skills and behaviour. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00121622
- Volume :
- 58
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Developmental Medicine & Child Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 117871089
- Full Text :
- https://doi.org/10.1111/dmcn.13169