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Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation.
- Source :
- BMC Complementary & Alternative Medicine; 8/26/2016, Vol. 16, p1-9, 9p, 1 Diagram, 5 Charts, 5 Graphs
- Publication Year :
- 2016
-
Abstract
- Background: Curcumin, a major active component of turmeric, has previously been reported to alleviate liver damage. Here, we investigated the mechanism by which turmeric and curcumin protect the liver against carbon tetrachloride (CCl<subscript>4</subscript>)-induced injury in rats. We hypothesized that turmeric extract and curcumin protect the liver from CCl<subscript>4</subscript>-induced liver injury by reducing oxidative stress, inhibiting lipid peroxidation, and increasing glutathione peroxidase activation. Methods: Chronic hepatic stress was induced by a single intraperitoneal injection of CCl<subscript>4</subscript> (0.1 ml/kg body weight) into rats. Turmeric extracts and curcumin were administered once a day for 4 weeks at three dose levels (100, 200, and 300 mg/kg/day). We performed ALT and AST also measured of total lipid, triglyceride, cholesterol levels, and lipid peroxidation. Result: We found that turmeric extract and curcumin significantly protect against liver injury by decreasing the activities of serum aspartate aminotransferase and alanine aminotransferase and by improving the hepatic glutathione content, leading to a reduced level of lipid peroxidase. Conclusions: Our data suggest that turmeric extract and curcumin protect the liver from chronic CCl<subscript>4</subscript>-induced injury in rats by suppressing hepatic oxidative stress. Therefore, turmeric extract and curcumin are potential therapeutic antioxidant agents for the treatment of hepatic disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIVER injuries
ANIMAL experimentation
ANTIOXIDANTS
BIOMARKERS
CHRONIC diseases
COLORIMETRY
STATISTICAL correlation
HIGH performance liquid chromatography
HISTOLOGICAL techniques
LIPID peroxidation (Biology)
RATS
RESEARCH funding
TURMERIC
PLANT extracts
OXIDATIVE stress
DATA analysis software
DESCRIPTIVE statistics
CURCUMIN
IN vitro studies
ONE-way analysis of variance
Subjects
Details
- Language :
- English
- ISSN :
- 14726882
- Volume :
- 16
- Database :
- Complementary Index
- Journal :
- BMC Complementary & Alternative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 117738041
- Full Text :
- https://doi.org/10.1186/s12906-016-1307-6