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Inflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma.
- Source :
- OncoImmunology; 2016, Vol. 5 Issue 8, p1-1, 1p
- Publication Year :
- 2016
-
Abstract
- Foxp3+CD4+regulatory T (Treg) cells are thought to express negligible levels of effector cytokines, and inhibit immune responses and inflammation. Here, we have identified a population of IL-8+Foxp3+CD4+T cells in human peripheral blood, which is selectively increased in the microenvironments of ulcerative colitis and colon carcinoma. Phenotypically, this population is minimally overlapping with IL-17+Foxp3+CD4+T cells, and is different from IL-8−Foxp3+CD4+T cells in the same microenvironment. 40–60% of IL-8+Foxp3+CD4+T cells exhibit naive phenotype and express CD127, whereas IL-8−Foxp3+CD4+cells are basically memory T cells and express minimal CD127. The levels of CXCR5 expression are higher in IL-8+Foxp3+cells than in IL-8−Foxp3+cells. IL-2 and TGFβ induce IL-8+Foxp3+T cells. Exogenous Foxp3 expression promotes IL-8+Foxp3+T cells and inhibits effector cytokine IFNγ and IL-2 expression. Furthermore, Foxp3 binds to IL-8 proximal promoter and increases its activity. Functionally, IL-8+Foxp3+T cells inhibit T cell proliferation and effector cytokine production, but stimulate inflammatory cytokine production in the colon tissues, and promote neutrophil trafficking through IL-8. Thus, IL-8+Foxp3+cells may be an “inflammatory” Treg subset, and possess inflammatory and immunosuppressive dual biological activities. Given their dual roles and localization, these cells may be in a unique position to support tumor initiation and development in human chronic inflammatory environment. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 21624011
- Volume :
- 5
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- OncoImmunology
- Publication Type :
- Academic Journal
- Accession number :
- 117673737
- Full Text :
- https://doi.org/10.1080/2162402X.2015.1105430