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An initial loading-dose vitamin D versus placebo after hip fracture surgery: randomized trial.
- Source :
- BMC Musculoskeletal Disorders; 8/11/2016, Vol. 17, p1-11, 11p, 1 Diagram, 3 Charts, 3 Graphs
- Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>Improving vitamin D (25-OHD) status may be an important modifiable factor that could reduce disability severity, fall-rates and mortality associated after hip fracture surgery. Providing a loading-dose post-surgery may overcome limitations in adherence to daily supplementation.<bold>Method: </bold>In this randomized, double-blind, placebo-controlled trial, 218 adults, aged 65-years or older, requiring hip fracture surgery were assigned to receive a single loading-dose of cholecalciferol (250,000 IU vitamin-D3, the REVITAHIP - Replenishment of Vitamin D in Hip Fracture strategy) or placebo, both receiving daily vitamin-D(800 IU) and calcium (500 mg) for 26-weeks. Outcome measures were 2.4 m gait-velocity, falls, fractures, death (Week-4), 25-OHD levels, quality-of-life measure (EuroQoL) and mortality at weeks-2, 4 and 26.<bold>Results: </bold>Mean age of 218 participants was 83.9(7.2) years and 77.1 % were women. Baseline mean 25-OHD was 52.7(23.5)nmol/L, with higher levels at Week-2 (73 vs 66 nmol/L; p = .019) and Week-4 (83 vs 75 nmol/L; p = .030) in the Active-group, but not at Week-26. At week-4, there were no differences in 2.4 m gait-velocity (0.42 m/s vs 0.39 m/s, p = .490), fractures (2.7 % vs 2.8 %, p = .964) but Active participants reported less falls (6.3 % vs 21.1 %, χ(2) = 4.327; p = 0.024), with no significant reduction in deaths at week-4 (1 vs 3, p = 0.295), higher percentage reporting 'no pain or discomfort' (96.4 % vs 88.8 %, p = 0.037), and trended for higher EuroQoL-scores (p = 0.092) at week-26. One case of hypercalcemia at week-2 normalised by week-4.<bold>Conclusion: </bold>Among older people after hip fracture surgery, the REVITAHIP strategy is a safe and low cost method of improving vitamin-D levels, reducing falls and pain levels.<bold>Trial Registration: </bold>The protocol for this study is registered with the Australian New Zealand Clinical Trials Registry ANZCTRN ACTRN12610000392066 (Date of registration: 14/05/2010). [ABSTRACT FROM AUTHOR]
- Subjects :
- VITAMIN D in the body
DRUG dosage
TOTAL hip replacement
PLACEBOS
ACCIDENTAL fall prevention
MEDICAL rehabilitation
RANDOMIZED controlled trials
CALCIUM
COMPARATIVE studies
DIETARY supplements
ACCIDENTAL falls
DIPHOSPHONATES
BONE fractures
HIP joint injuries
HYPERCALCEMIA
RESEARCH methodology
MEDICAL cooperation
QUALITY of life
QUESTIONNAIRES
RESEARCH
SURVIVAL
EVALUATION research
BLIND experiment
CHOLECALCIFEROL
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 14712474
- Volume :
- 17
- Database :
- Complementary Index
- Journal :
- BMC Musculoskeletal Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 117412511
- Full Text :
- https://doi.org/10.1186/s12891-016-1174-9