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Non-surgical periodontal treatment in conjunction with 3 or 7 days systemic administration of amoxicillin and metronidazole in severe chronic periodontitis patients. A placebo-controlled randomized clinical study.
- Source :
- Journal of Clinical Periodontology; Sep2016, Vol. 43 Issue 9, p767-777, 11p, 1 Diagram, 3 Charts
- Publication Year :
- 2016
-
Abstract
- Aim To evaluate the effect of 3 or 7 days systemic administration of amoxicillin ( AMX) and metronidazole ( MET) or placebo as adjunct to non-surgical periodontal treatment in severe chronic periodontitis patients. Methods One hundred and two patients with severe chronic periodontitis [e.g. ≥1 site with probing pocket depth ( PD) ≥ 6 mm per quadrant] were randomly divided into three equally sized groups and treated with either scaling and root planing within 24 h ( SRP) + placebo (Group A) or SRP + AMX + MET (both 500 mg × 3 times daily) for 3 days (Group B) or SRP + AMX + MET (both 500 mg × 3 times daily) for 7 days (Group C). PD, clinical attachment level ( CAL), bleeding on probing ( BOP), full-mouth plaque scores ( FMPS) and gingival bleeding index ( GBI) were assessed prior to treatment (baseline), and at 3 and 6 months post-treatment. The primary outcome variable was the difference (Δ) in the number of sites with PD ≥ 6 mm. Results Ninety-one patients completed the study. At both 3 and 6 months, all three treatment protocols resulted in statistically significant improvements compared to baseline for all evaluated clinical parameters ( p < 0.001). At 6 months, a statistically significantly greater reduction in the mean number of sites with PD ≥ 6 mm was observed in group B (28.62 ± 15.32 sites) and group C (30.45 ± 15.04 sites) compared to the placebo group (17.10 ± 14.68 sites). Furthermore, both the 3- and the 7-day antibiotic regimen resulted in statistically significantly higher clinical improvements compared to the placebo group ( p < 0.05). Conclusion The present findings indicate that in patients with severe chronic periodontitis, non-surgical periodontal therapy in conjunction with a 3 or 7 days systemic administration of AMX + MET may lead to significantly greater clinical improvements compared to non-surgical therapy alone. [ABSTRACT FROM AUTHOR]
- Subjects :
- PATIENTS
AMOXICILLIN
ANALYSIS of covariance
CHRONIC diseases
CONFIDENCE intervals
DENTAL plaque
DENTAL scaling
DRUG side effects
LONGITUDINAL method
METRONIDAZOLE
PERIODONTITIS
PERIODONTIUM examination
PLACEBOS
PROBABILITY theory
SMOKING
T-test (Statistics)
TOOTH root planing
RANDOMIZED controlled trials
TREATMENT effectiveness
PRE-tests & post-tests
BLIND experiment
DATA analysis software
DESCRIPTIVE statistics
ODDS ratio
MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 43
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 117264611
- Full Text :
- https://doi.org/10.1111/jcpe.12559