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Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men.
- Source :
- European Journal of Clinical Nutrition; Jan2004, Vol. 58 Issue 1, p40-45, 6p
- Publication Year :
- 2004
-
Abstract
- OBJECTIVE:: To investigate whether the daily intake of red wine (RW) at a dose which inversely correlates with cardiovascular disease (CVD) risk modulates immune functions in healthy men. DESIGN:: Randomized single-blind trial with four intervention periods. SETTING:: The Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany. SUBJECTS:: A total of 24 healthy males with moderate alcohol consumption patterns were recruited and all completed the study. INTERVENTION:: Participants consumed 500?ml of RW (12% ethanol (ETOH)) or 500?ml of a 12% ETOH dilution per day for a period of 2 weeks. To control the potential effects of RW polyphenols, accordingly 500?ml/day of dealcoholized red wine (DRW) and of red grape juice (RGJ) were given. The following immune parameters were measured before beverage consumption and at 1 and 2 weeks following beverage consumption: phagocytic activity of neutrophils and monocytes, production of tumor necrosis factor-alpha (TNFa), interleukin-2 and -4, transforming growth factor-ß, TNFa mRNA, lymphocyte proliferation, lytic activity of natural killer cells, and percentage of apoptotic lymphocytes. RESULTS:: Consumption of a moderate volume of alcohol with RW and with a 12% ETOH dilution had no effect on immune functions in healthy males. Consumption of polyphenol-rich beverages (DRW and RGJ) did not affect immunity-related parameters. CONCLUSIONS:: Daily moderate consumption of alcohol and of RW for 2 weeks at doses which inversely correlate with CVD risk has no adverse effects on human immune cell functions. Polyphenol-rich beverages such as RGJ and DRW further do not suppress immune responses in healthy men. SPONSORSHIP:: The Federal Ministry of Consumer Protection, Food, and Agriculture, Germany.European Journal of Clinical Nutrition (2004) 58, 40-45. doi:10.1038/sj.ejcn.1601742 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09543007
- Volume :
- 58
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 11724228
- Full Text :
- https://doi.org/10.1038/sj.ejcn.1601742