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Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.
- Source :
- PLoS Pathogens; 8/3/2016, Vol. 12 Issue 8, p1-24, 24p
- Publication Year :
- 2016
-
Abstract
- The loss of HIV-specific CD8<superscript>+</superscript> T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8<superscript>+</superscript> T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8<superscript>+</superscript> T cell functional evolution from primary to chronic HIV infection. We observed a profound expansion of perforin<superscript>+</superscript> CD8<superscript>+</superscript> T cells immediately following HIV infection that quickly waned after acute viremia resolution. Selective expression of the effector-associated transcription factors T-bet and eomesodermin in cytokine-producing HIV-specific CD8<superscript>+</superscript> T cells differentiated HIV-specific from bulk memory CD8<superscript>+</superscript> T cell effector expansion. As infection progressed expression of perforin was maintained in HIV-specific CD8<superscript>+</superscript> T cells with high levels of T-bet, but not necessarily in the population of T-bet<superscript>Lo</superscript> HIV-specific CD8<superscript>+</superscript> T cells that expand as infection progresses. Together, these data demonstrate that while HIV-specific CD8<superscript>+</superscript> T cells in acute HIV infection initially possess cytolytic potential, progressive transcriptional dysregulation leads to the reduced CD8<superscript>+</superscript> T cell perforin expression characteristic of chronic HIV infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYTOTOXIC T cells
HIV infections
T cells
VIREMIA
PERFORINS
PROTEIN expression
Subjects
Details
- Language :
- English
- ISSN :
- 15537366
- Volume :
- 12
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- PLoS Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 117167514
- Full Text :
- https://doi.org/10.1371/journal.ppat.1005805