Back to Search
Start Over
High serum erythropoietin levels are related to heart failure development in subjects from the general population with albuminuria: data from PREVEND.
- Source :
- European Journal of Heart Failure; Jul2016, Vol. 18 Issue 7, p814-821, 8p, 4 Charts, 2 Graphs
- Publication Year :
- 2016
-
Abstract
- <bold>Aims: </bold>In patients with heart failure (HF), serum erythropoietin (EPO) levels are elevated and associated with disease severity and outcome. Whether endogenous EPO levels are prospectively associated with the development of HF or cardiovascular events in the general population is unknown.<bold>Methods and Results: </bold>Serum EPO levels were measured at baseline in 6686 subjects enrolled in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) study. Mean age (±SD) was 53 ± 12 years, 49.8% were male, and the median (interquartile range) EPO level was 7.7 (5.9-10.2) IU/L. During a median follow-up of 8.3 (7.7-8.8) years, 209 (3.1%) subjects were newly diagnosed with HF, 97 (1.5%) died of a cardiovascular cause, and 386 (6.0%) subjects had a non-fatal cardiovascular event (277 cardiac events and 93 strokes). Each doubling of EPO level was multivariably associated with new-onset HF [hazard ratio (HR) 1.32, 95% confidence interval (CI) 1.03-1.69, P = 0.031]. EPO levels showed interaction with urinary albumin excretion (P = 0.006) and were only associated with HF in subjects with albuminuria (HR 1.51, 95% CI 1.13-2.03, P = 0.005). There was an independent association of EPO levels with stroke in women (HR 1.82, 95% CI 1.24-2.65, P = 0.002), but not in men. No association was observed for EPO levels with other cardiovascular events or cardiovascular mortality.<bold>Conclusion: </bold>High serum EPO levels are independently associated with an increased risk of new-onset HF in subjects with albuminuria. More research into the pathophysiological mechanisms linking EPO levels to HF is needed to understand this association. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEART failure
HEART failure patients
HEART failure treatment
ERYTHROPOIETIN
BLOOD serum analysis
ALBUMINURIA
DIAGNOSIS
CARDIOVASCULAR disease related mortality
CORONARY disease
MULTIVARIATE analysis
MYOCARDIAL infarction
MYOCARDIAL revascularization
PROGNOSIS
SEX distribution
STROKE
PROPORTIONAL hazards models
Subjects
Details
- Language :
- English
- ISSN :
- 13889842
- Volume :
- 18
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- European Journal of Heart Failure
- Publication Type :
- Academic Journal
- Accession number :
- 116858233
- Full Text :
- https://doi.org/10.1002/ejhf.484