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Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethyl.

Authors :
A.Bassig, Bryan
Luoping Zhang
Vermeulen, Roel
Xiaojiang Tang
Guilan Li
Wei Hu
Weihong Guo
Purdue, Mark P.
Songnian Yin
Rappaport, Stephen M.
Min Shen
Zhiying Ji
Chuangyi Qiu
Yichen Ge
Hosgood, H. Dean
Reiss, Boris
Banghua Wu
Yuxuan Xie
Laiyu Li
Fei Yue
Source :
Carcinogenesis; Jul2016, Vol. 37 Issue 7, p692-700, 9p
Publication Year :
2016

Abstract

Benzene, formaldehyde (FA) and trichloroethylene (TCE) are ubiquitous chemicals in workplaces and the general environment. Benzene is an established myeloid leukemogen and probable lymphomagen. FA is classified as a myeloid leukemogen but has not been associated with non-Hodgkin lymphoma (NHL), whereas TCE has been associated with NHL but not myeloid leukemia. Epidemiologic associations between FA and myeloid leukemia, and between benzene, TCE and NHL are, however, still debated. Previously, we showed that these chemicals are associated with hematotoxicity in cross-sectional studies of factory workers in China, which included extensive personal monitoring and biological sample collection. Here, we compare and contrast patterns of hematotoxicity, monosomy 7 in myeloid progenitor cells (MPCs), and B-cell activation biomarkers across these studies to further evaluate possible mechanisms of action and consistency of effects with observed hematologic cancer risks. Workers exposed to benzene or FA, but not TCE, showed declines in cell types derived from MPCs, including granulocytes and platelets. Alterations in lymphoid cell types, including B cells and CD4+ T cells, and B-cell activation markers were apparent in workers exposed to benzene or TCE. Given that alterations in myeloid and lymphoid cell types are associated with hematological malignancies, our data provide biologic insight into the epidemiological evidence linking benzene and FA exposure with myeloid leukemia risk, and TCE and benzene exposure with NHL risk. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01433334
Volume :
37
Issue :
7
Database :
Complementary Index
Journal :
Carcinogenesis
Publication Type :
Academic Journal
Accession number :
116689221
Full Text :
https://doi.org/10.1093/carcin/bgw053