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Revisiting post-infectious glomerulonephritis in the emerging era of C3 glomerulopathy.
- Source :
- Clinical Kidney Journal; Jun2016, Vol. 9 Issue 3, p397-402, 6p
- Publication Year :
- 2016
-
Abstract
- Background:: Post-infectious glomerulonephritis (PIGN) is an immune complex-mediated glomerular injury that typically resolves. Dominant C3 deposition is characteristic of PIGN, but with the emergence of C3 glomerulonephritis (C3GN) as a distinct entity, it is unclear how the pathologic similarities between PIGN and C3GN should be reconciled. Therefore, nephrologists and nephropathologists need additional guidance at the time of biopsy. Methods: We studied 23 pediatric and young adult patients diagnosed with PIGN. Patients were divided into two groups, one with co-dominance between C3 and immunoglobulins and the other meeting proposed diagnostic criteria for C3GN. Clinical and pathological features were compared. Results: No clinical and/or pathological features could distinguish between those with C3-co-dominant deposits and those with C3 dominance. Nearly all patients in both groups regained their baseline renal function without clinical intervention. Conclusions: Although the identification of abnormalities of the alternative pathway of complement is characteristic of C3GN, testing is not widely available and the turnaround time often exceeds 1 month. Our study found that PIGN with either codominant or dominant C3 deposition in a cohort of young patients has excellent short-term outcomes. Close clinical observation for persistent abnormalities, such as hypocomplementemia, prolonged hematuria or proteinuria, is recommended to single out patients that may harbor intrinsic complement abnormalities. [ABSTRACT FROM AUTHOR]
- Subjects :
- COMPLEMENT (Immunology)
KIDNEY abnormalities
KIDNEY diseases
Subjects
Details
- Language :
- English
- ISSN :
- 20488505
- Volume :
- 9
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical Kidney Journal
- Publication Type :
- Academic Journal
- Accession number :
- 116178359
- Full Text :
- https://doi.org/10.1093/ckj/sfw032