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Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women.
- Source :
- Brain Imaging & Behavior; Jun2016, Vol. 10 Issue 2, p581-593, 13p
- Publication Year :
- 2016
-
Abstract
- Anxiety disorders are characterized by hyperactivity in both the amygdala and the anterior insula. Interventions that normalize activity in these areas may therefore be effective in treating anxiety disorders. Recently, there has been significant interest in the potential use of oxytocin (OT), as well as vasopressin (AVP) antagonists, as treatments for anxiety disorders. In this double-blind, placebo-controlled, pharmaco- fMRI study, 153 men and 151 women were randomized to treatment with either 24 IU intranasal OT, 20 IU intranasal AVP, or placebo and imaged with fMRI as they played the iterated Prisoner's Dilemma game with same-sex human and computer partners. In men, OT attenuated the fMRI response to unreciprocated cooperation (CD), a negative social interaction, within the amygdala and anterior insula. This effect was specific to interactions with human partners. In contrast, among women, OT unexpectedly attenuated the amygdala and anterior insula response to unreciprocated cooperation from computer but not human partners. Among women, AVP did not significantly modulate the response to unreciprocated cooperation in either the amygdala or the anterior insula. However, among men, AVP attenuated the BOLD response to CD outcomes with human partners across a relatively large cluster including the amygdala and the anterior insula, which was contrary to expectations. Our results suggest that OT may decrease the stress of negative social interactions among men, whereas these effects were not found in women interacting with human partners. These findings support continued investigation into the possible efficacy of OT as a treatment for anxiety disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- BRAIN physiology
INTRANASAL medication
ANXIETY
BASAL ganglia
CEREBRAL cortex
COMPARATIVE studies
COOPERATIVENESS
INTERPERSONAL relations
MAGNETIC resonance imaging
RESEARCH methodology
MEDICAL cooperation
OXYTOCIN
RESEARCH
RESEARCH funding
STATISTICAL sampling
SOCIAL skills
PSYCHOLOGICAL stress
EVALUATION research
VASOPRESSIN
RANDOMIZED controlled trials
BLIND experiment
PHYSIOLOGY
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 19317557
- Volume :
- 10
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Brain Imaging & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 116148061
- Full Text :
- https://doi.org/10.1007/s11682-015-9411-7