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Asymmetric Induction at Remote Quaternary Centers of Cyclohexadienones by Rhodium-Catalyzed Conjugate Hydrosilylation.
- Source :
- Angewandte Chemie International Edition; 6/6/2016, Vol. 55 Issue 24, p6873-6876, 4p
- Publication Year :
- 2016
-
Abstract
- The enantioselective desymmetrizing conjugate hydrosilylation of prochiral differently γ,γ-disubstituted cyclohexadienone derivatives 2 to furnish the corresponding cyclohexenones 4 with a remote chiral all-carbon quaternary center at the γ position is described. Chiral rhodium-bis(oxazolinyl)phenyl complexes 1 were effective catalysts for this transformation. This catalytic system was extended to the asymmetric transformation of spirocarbocyclic cyclohexadienones 5 to give the corresponding products 6 with high enantiomeric ratios. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYDROSILYLATION
CYCLOHEXADIENONES
ENANTIOMERS
RHODIUM
CHIRALITY
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 55
- Issue :
- 24
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 115813456
- Full Text :
- https://doi.org/10.1002/anie.201601636