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Long chain polyunsaturate supplementation does not induce excess lipid peroxidation of piglet tissues.

Authors :
Sarkadi-Nagy, Eszter
Meng-Chuan Huang, Eszter
Guan-Yeu Diau, Eszter
Kirwan, Ryan
Chueh Chao, Angela
Tschanz, Carolyn
Brenna, J. Thomas
Source :
European Journal of Nutrition; 2003, Vol. 42 Issue 5, p293-296, 4p, 1 Chart, 1 Graph
Publication Year :
2003

Abstract

Background Addition of highly polyunsaturated fatty acids to infant formulas raises the possibility of increased lipid peroxidation. Aim of the study We determined the effects of increasing levels of dietary docosahexaenoic acid DHA) and arachidonic acid (AA) on lipid peroxidation and peroxidative potential in piglet tissues. Methods Four groups of piglets (n=6) were bottle-fed a formula containing one of four treatments: no long chain fatty acid (Diet 0) and three different levels of DHA/AA at 1-fold (0.3%/0.6% FA; Diet 1) 2-fold (0.6%/1.2% FA; Diet 2) and 5-fold (1.5%/3% FA; Diet 5) concentration used in some human infant formulas, and all with equal amount of vitamin E (5.7 IU/ 100 kcal formula) for four weeks. Results There were no significant differences between the groups in conjugated diene and glutathione (GSH) levels in the liver, and thiobarbituric acid-reactive substance (TBARS) in plasma. TBARS levels of the erythrocyte membranes increased in a dose-dependent manner when in vitro oxidation was induced with 10 mM hydrogen peroxide (H[sub2]O[sub2]) for 30 minutes. The TBARS levels of the liver homogenates of the Diet 5 and Diet 2 groups were significantly different than those of the membranes of the Diet 0 group when the in vitro oxidation was induced with H[sub2]O[sub2]. Conclusion The results show that dietary vitamin E effectively prevented lipid peroxidation at the LCP concentrations investigated and suggest that levels presently in infant formulas are sufficient. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14366207
Volume :
42
Issue :
5
Database :
Complementary Index
Journal :
European Journal of Nutrition
Publication Type :
Academic Journal
Accession number :
11570671
Full Text :
https://doi.org/10.1007/s00394-003-0422-6