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Cardiovascular disease predicts diabetic peripheral polyneuropathy in subjects with type 2 diabetes: A 10-year prospective study.
- Source :
- European Journal of Cardiovascular Nursing; Jun2016, Vol. 15 Issue 4, p248-254, 7p
- Publication Year :
- 2016
-
Abstract
- Background: The relationship between cardiovascular disease and diabetic peripheral neuropathy is mainly sustained by data retrieved from cross-sectional studies focused on cardiovascular risk factors. We aimed to assess the presence of cardiovascular disease as a risk factor for developing diabetic peripheral neuropathy in a type 2 diabetes mellitus population. Method: A 10-year prospective, primary care, multicentre study in a randomly selected cohort. Cardiovascular disease presence included stroke, coronary artery disease and/or peripheral ischaemia. Diabetic peripheral neuropathy diagnosis was based on clinical neurological examination as well as the neuropathy symptoms score and nerve conduction studies. Results: Three hundred and ten (N=310) patients were initially recruited. Two-hundred and sixty seven (N=267) patients were included in the study. Diabetic peripheral neuropathy cumulative incidence was 18.3% (95% confidence intervals 14.1–23.4; N=49). Diabetic peripheral neuropathy development was significantly more frequent in participants presenting with cardiovascular disease at baseline (P=0.01). In the final logistic regression analysis, the presence of cardiovascular disease remained associated with an increased risk for diabetic peripheral neuropathy (odds ratio 2.32, 95% confidence intervals 1.03–5.22) in addition to diabetes duration and low density lipoprotein-cholesterol levels. Conclusions: In our series, type 2 diabetes mellitus patients with cardiovascular disease at baseline present with an increased risk of developing diabetic peripheral neuropathy at 10 years of follow-up. Our results suggest that measures aimed at the prevention, control and treatment of cardiovascular disease can also help prevent diabetic peripheral neuropathy development. [ABSTRACT FROM AUTHOR]
- Subjects :
- DIABETIC neuropathies
CARDIOVASCULAR diseases
CHI-squared test
PEOPLE with diabetes
LONGITUDINAL method
MEDICAL cooperation
TYPE 2 diabetes
RESEARCH
RESEARCH funding
MULTIPLE regression analysis
CROSS-sectional method
DATA analysis software
DESCRIPTIVE statistics
DISEASE complications
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 14745151
- Volume :
- 15
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- European Journal of Cardiovascular Nursing
- Publication Type :
- Academic Journal
- Accession number :
- 115682635
- Full Text :
- https://doi.org/10.1177/1474515114565215