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Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity.
- Source :
- Journal of Immunology Research; 3/17/2016, p1-10, 10p
- Publication Year :
- 2016
-
Abstract
- Lipopolysaccharide- (LPS-) mediated systemic inflammation plays a critical role in neurodegenerative diseases. The present study was conducted to evaluate the protective effects of epigallocatechin gallate (EGCG), the major component in green tea, on LPS-mediated inflammation and neurotoxicity. LPS treatment of macrophages induced expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6). However, EGCG pretreatment of macrophages significantly inhibited LPS-mediated induction of these cytokines. In addition, EGCG significantly diminished LPS-induced inflammatory cytokines in the peripheral mononuclear blood cells (PBMCs). Supernatant from EGCG-pretreated and LPS-activated macrophage cultures was found to be less cytotoxic to neurons than that from non-EGCG-pretreated and LPS-activated macrophage cultures. Furthermore, EGCG treatment of neurons could inhibit LPS-induced production of reactive oxygen species (ROS). Thus EGCG represents a potent and useful neuroprotective agent for inflammation-mediated neurological disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIPOPOLYSACCHARIDES
CELL-mediated cytotoxicity
INFLAMMATORY mediators
TREATMENT of neurodegeneration
EPIGALLOCATECHIN gallate
THERAPEUTICS
INFLAMMATION treatment
NEURAL physiology
INFLAMMATION prevention
REACTIVE oxygen species
ANIMALS
CELL culture
CELL physiology
CULTURE media (Biology)
FLAVONOIDS
IMMUNITY
INTERLEUKIN-1
INTERLEUKINS
MACROPHAGES
NEURONS
POLYMERASE chain reaction
RATS
RESEARCH funding
TEA
TUMOR necrosis factors
NEUROPROTECTIVE agents
MONONUCLEAR leukocytes
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 23148861
- Database :
- Complementary Index
- Journal :
- Journal of Immunology Research
- Publication Type :
- Academic Journal
- Accession number :
- 115646803
- Full Text :
- https://doi.org/10.1155/2016/4962351