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Carbohydrate supplementation does not blunt the prolonged exercise-induced reduction of in vivo immunity.
- Source :
- European Journal of Nutrition; Jun2016, Vol. 55 Issue 4, p1583-1593, 11p, 4 Charts, 2 Graphs
- Publication Year :
- 2016
-
Abstract
- Background: Carbohydrate (CHO) supplementation during prolonged exercise is widely acknowledged to blunt in vitro immunoendocrine responses, but no study has investigated in vivo immunity. Purpose: To determine the effect of CHO supplementation during prolonged exercise on in vivo immune induction using experimental contact hypersensitivity with the novel antigen diphenylcyclopropenone (DPCP). Methods: In a double-blind design, 32 subjects were randomly assigned to 120 min of treadmill exercise at 60 % $$\dot{V}{\text{O}}_{2} { \hbox{max} }$$ with CHO (Ex-CHO) or placebo (Ex-PLA) supplementation. Responses were also compared to 16 resting control (CON) subjects from a previous study (for additional comparison with a resting non-exercise condition). Standardised diets (24 h pre-trial) and breakfasts (3.5 h pre-trial) were provided. Subjects received a primary DPCP exposure (sensitisation) 20 min after trial completion, and exactly 28 days later the strength of immune reactivity was quantified by magnitude of the cutaneous response (skin-fold thickness and erythema) to a low dose-series DPCP challenge. Stress hormones and leucocyte trafficking were also monitored. Results: CHO supplementation blunted the cortisol and leucocyte trafficking responses, but there was no difference ( P > 0.05) between Ex-CHO and Ex-PLA in the in vivo immune responses (e.g. both ~46 % lower than CON for skin-fold response). Conclusions: CHO supplementation does not influence the decrease in in vivo immunity seen after prolonged exercise. The effects with more stressful (or fasted) exercise remain to be determined. However, there appears to be no benefit under the conditions of the present study, which have practical relevance to what many athletes do in training or competition. [ABSTRACT FROM AUTHOR]
- Subjects :
- BLOOD sugar analysis
ERYTHEMA
EXERCISE
IMMUNE system physiology
ADRENALINE
AEROBIC exercises
ANALYSIS of variance
ANTHROPOMETRY
BEVERAGES
CARDIOPULMONARY system
CONFIDENCE intervals
CONTACT dermatitis
DOSE-response relationship in biochemistry
EXERCISE physiology
EXERCISE tests
CARBOHYDRATE content of food
HEART rate monitoring
HORMONES
HYDROCORTISONE
NEUTROPHILS
NORADRENALINE
PROBABILITY theory
QUESTIONNAIRES
STATISTICAL sampling
SKINFOLD thickness
STATISTICS
T-test (Statistics)
DATA analysis
TREADMILLS
RANDOMIZED controlled trials
OXYGEN consumption
BLIND experiment
DESCRIPTIVE statistics
LEUKOCYTE count
ONE-way analysis of variance
IN vivo studies
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 55
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 115529573
- Full Text :
- https://doi.org/10.1007/s00394-015-0977-z