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MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer.
- Source :
- Tumor Biology (Springer Science & Business Media B.V.); Jun2016, Vol. 37 Issue 6, p7245-7254, 10p
- Publication Year :
- 2016
-
Abstract
- Acquisition of gemcitabine resistance in breast cancer has not been fully clarified. Prior studies suggest that miRNAs are important to chemoresistance in solid tumors and we confirmed that miR-21 is involved in the development of gemcitabine resistance. Epithelial-to-mesenchymal transition (EMT) and AKT pathway activation were noted to be important to this resistance as well. PTEN, a direct target gene of miR-21, was significantly downregulated in gemcitabine-resistant breast cancer cells and restoration of PTEN expression blocked miR-21-induced EMT and gemcitabine resistance. Our data offer novel insight into gemcitabine resistance in breast cancer and suggest that miR-21 may be used to predict optimal breast cancer therapy and may be a potential therapeutic target for reversing gemcitabine resistance. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10104283
- Volume :
- 37
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Tumor Biology (Springer Science & Business Media B.V.)
- Publication Type :
- Academic Journal
- Accession number :
- 115528771
- Full Text :
- https://doi.org/10.1007/s13277-015-4604-7