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Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: a systematic review and meta-analysis.
- Source :
- Journal of Clinical Periodontology; Jun2016, Vol. 43 Issue 6, p520-530, 11p, 1 Diagram, 5 Charts
- Publication Year :
- 2016
-
Abstract
- Focused question What is the clinical influence of probiotics as an adjunctive therapy of scaling and root planing ( SRP) when compared with SRP alone or in combination with placebo in the treatment of chronic periodontitis ( CP). Methods Electronic databases were searched up to July 2015. Randomized controlled trials ( RCTs) comparing SRP + probiotic versus SRP were included. PPD reduction and CAL gain were selected as primary outcome variables. Results Independent screening resulted in four eligible publications for the systematic review and three were included in the meta-analysis. Meta-analysis showed a statistically significant CAL gain (−0.42 mm, p = 0.002) and bleeding on probing ( BOP) reduction (−14.66, p = 0.003) for SRP + probiotic treatment versus SRP at short-term. Only a tendency ( p = 0.06) has been observed in terms of overall PPD reduction, whereas results were significant when stratified for moderate (−0.18, p = 0.001) and deep pockets (−0.67, p < 0.001). Conclusion Within the limitations of this study, the findings of this meta-analysis seem to support the adjunctive use of L. reuteri to SRP in CP treatment at short-term, especially in deep pockets. Heterogeneity and limited available data may reduce the impact of these conclusions. Future long-term RCTs evaluating the clinical efficacy of adjunctive probiotics to SRP are needed. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of probiotics
PERIODONTITIS treatment
CHRONIC disease treatment
BACTERIA
BIOFILMS
CHI-squared test
CHRONIC diseases
COMBINED modality therapy
COMPARATIVE studies
CONFIDENCE intervals
DATABASES
DENTAL plaque
DENTAL scaling
HOST-bacteria relationships
MEDICAL databases
INFORMATION storage & retrieval systems
MEDICAL information storage & retrieval systems
MEDLINE
META-analysis
PERIODONTITIS
PROBABILITY theory
TOOTH care & hygiene
RANDOMIZED controlled trials
TREATMENT effectiveness
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 43
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 115421162
- Full Text :
- https://doi.org/10.1111/jcpe.12545