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Cover Picture: Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (−)-Lyngbyaloside B (Chem. Eur. J. 20/2016).
- Source :
- Chemistry - A European Journal; 5/10/2016, Vol. 22 Issue 20, p6697-6697, 1p
- Publication Year :
- 2016
-
Abstract
- Structural reassignment: Total synthesis of the proposed and correct structures of (−) ‐ lyngbyaloside B (see figure), a marine macrolide glycoside, has been achieved. The synthesis entailed an Abiko – Masamune aldol reaction, a vinylogous Mukaiyama aldol reaction, and an acyl ketene macrocyclization to forge the 14 ‐ membered macrolactone. The present work established the complete stereostructure of this natural product in an unambiguous manner. More information can be found in the Full Paper by H. Fuwa et al. on page 6815 ff. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHEMICAL synthesis
MACROLIDE antibiotics
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 22
- Issue :
- 20
- Database :
- Complementary Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 115061952
- Full Text :
- https://doi.org/10.1002/chem.201601249