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IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis.
- Source :
- Expert Review of Gastroenterology & Hepatology; May2016, Vol. 10 Issue 5, p659-663, 5p
- Publication Year :
- 2016
-
Abstract
- Background: Autoimmune hepatitis (AIH) is a chronic long-lasting hepatocellular inflammation associated with circulating auto antibodies. In addition to the genetic component, several cytokines have been implicated to be involved in AIH. This study was performed to investigate potential associations of AIH with IL4 gene variants. Method: The studied alleles and genotypes included: IL4G/T allele polymorphisms at position -1098 and C/T allele polymorphisms at two positions (-33 and -590) on the IL4 gene, in addition to the A/G allele polymorphisms at position +1902 on the IL4RA gene. Result: The IL4 C allele and CC genotype at position -590 and TT genotype at position -33 had a significantly higher frequency in AIH patients. Conclusion: This study identified the IL4 C allele and CC genotype susceptibility gene in AIH, which will provide better insights into the mechanisms of AIH and potential therapeutic interventions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17474124
- Volume :
- 10
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Expert Review of Gastroenterology & Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 114606828
- Full Text :
- https://doi.org/10.1586/17474124.2016.1139449