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Risk of new-onset heart failure in patients using sitagliptin: a population-based cohort study.
- Source :
- Diabetic Medicine; May2016, Vol. 33 Issue 5, p621-630, 10p, 1 Diagram, 3 Charts
- Publication Year :
- 2016
-
Abstract
- Aims To examine whether patients using sitagliptin at the time of an acute coronary syndrome event are at increased risk of incident heart failure compared with those not exposed. Methods Using US claims data, people with diabetes without a history of heart failure in the 3 years before hospitalization for acute coronary syndrome were identified for the period 2004 to 2010. We used a nested case-control design, whereby cases were patients who developed incident heart failure <30 days after admission to hospital for acute coronary syndrome and were matched by age and sex with up to 10 controls with no heart failure. Subjects exposed or not exposed to sitagliptin in the 90 days before acute coronary syndrome admission were compared using conditional logistic regression after adjustment for clinical and laboratory data, healthcare utilization and propensity scores. Results In total, 457 cases of heart failure developing de novo after diagnosis of acute coronary syndrome were matched to 4570 controls. The average age of the subjects was 55 years and 65% were male. Overall, 11 of 147 (7%) people exposed to sitagliptin developed heart failure compared with 446 of the 4880 people not exposed (9%, adjusted odds ratio 0.75, 95% CI 0.38-1.46; P=0.40). Sitagliptin exposure before acute coronary syndrome was not associated with an increased risk of death or heart failure combined (7% vs 9%, adjusted odds ratio 0.66, 95% CI 0.34-1.28). Conclusions In our sample of patients who are at high risk of heart failure after acute coronary syndrome, sitagliptin exposure was not associated with an increased risk of de novo heart failure. [ABSTRACT FROM AUTHOR]
- Subjects :
- ENZYME inhibitors
HEART failure
HYPERTENSION
CARDIOVASCULAR disease diagnosis
TYPE 2 diabetes treatment
HYPOGLYCEMIC agents
HEART failure risk factors
ACUTE coronary syndrome
TYPE 2 diabetes complications
AGE distribution
CONFIDENCE intervals
DEMOGRAPHY
PEOPLE with diabetes
GLOMERULAR filtration rate
GLYCOSYLATED hemoglobin
INSURANCE
LONGITUDINAL method
TYPE 2 diabetes
NOSOLOGY
POPULATION
RESEARCH funding
COMORBIDITY
LOGISTIC regression analysis
DATA analysis
TREATMENT effectiveness
CONTROL groups
CONFOUNDING variables
ODDS ratio
SITAGLIPTIN
EVALUATION
DIAGNOSIS
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 07423071
- Volume :
- 33
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Diabetic Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 114604685
- Full Text :
- https://doi.org/10.1111/dme.12867